Otsuka Pharmaceutical (TYO:4578) and Lundbeck said last week that its extended-release injectable aripiprazole suspension, Abilify Maintena, won FDA approval as a maintenance monotherapy for adults with bipolar I disorder. The once-monthly intramuscular formulation was created by Otsuka and co-developed and commercialized with Lundbeck, the companies reported. A late-stage trial showed that Abilify Maintena delayed the time […]
Neurological
Prolonging the lives & independence of Alzheimer’s patients with artificial intelligence
With modern medicine and public health measures extending the average person’s life expectancy, a growing population is coming face to face with the challenges of age – including cognitive decline. Addressing the needs of people dealing with cognitive change is no simple task. And today’s healthcare workers are hungry for objective, meaningful data to help […]
Nanotech derived from amniotic stem cells could help treat brain cancer
Creative Medical Technology Holdings (OTC:CELZ) touted its exosome technology today, reporting that it demonstrated an ability to regenerate healthy brain cells while selectively halting the growth of glioma brain cancer cells in a preclinical model. The company’s exosomes are vesicles harvested from amniotic stem cell technology, which it licensed from the University of California San […]
Novocure brings Optune tech to drug trial for glioblastoma
Novocure (NSDQ:NVCR) said today that it joined a Phase Ib study to evaluate the safety of Celgene‘s (NSDQ:CELG) marizomib and temozolomide in combination with Optune for patients with newly-diagnosed glioblastoma. The trial is the first to assess Optune, the company’s “Tumor Treating Fields” delivery device, in combination with an investigational drug. Celgene and Triphase changed their ongoing […]
Parkinson’s protein to take a trip into space
The Michael J. Fox Foundation for Parkinson’s Research and the Center for the Advancement of Science in Space yesterday inked a collaboration to send a protein linked to Parkinson’s disease to the International Space Station. The researchers plan to evaluate the protein’s growth under microgravity conditions, which could foster larger, more regular LRRK2 protein crystals […]
Report: Pipeline of Alzheimer’s drugs ‘due for big victories’ in next 5 years
There are twenty-seven Alzheimer’s drugs in late-stage clinical trials and eight candidates in Phase II programs that could launch in the next 5 years, according to an analysis presented this week at the Alzheimer’s Association International Conference. “The Alzheimer’s disease pipeline, marred by decades of failures and underinvestment, is due for big victories,” UsAgainstAlzheimer’s co-founder […]
Epilepsy biomarker could aid in early detection, targeted treatment
Researchers from the University of Illinois at Chicago College of Medicine have identified a unique chemical biomarker associated with epileptic brain tissue, according to an article published in the journal Epilepsia. The chemical signature can be detected noninvasively and could enable physicians to precisely locate small regions of abnormal brain tissue in early-stage patients. The researchers […]
Corium touts clinical data for transdermal delivery of Alzheimer’s drug
Corium (NSDQ:CORI) touted data today from a pilot bioequivalence study, comparing its Corplex Donepezil transdermal patch to oral Aricept as delivery method for the most commonly prescribed treatment for Alzheimer’s disease. Data from the pilot study demonstrated that Corium’s transdermal patch met the criteria for bioequivalence to oral Aricept, as measured by primary pharmacokinetic endpoints […]
Study: Nanomedicine shuts down cells that drive cancer growth in glioblastoma
Researchers from Northwestern Medicine have developed lipid polymer-based nanoparticles that target key cancer drivers, called brain tumor initiating cells, in a mouse model of glioblastoma brain tumors. “BTICs are malignant brain tumor populations that underlie the therapy resistance, recurrence and unstoppable invasion commonly encountered by glioblastoma patients after the standard treatment regimen of surgical resection, […]
Tiny bubbles get past blood-brain barrier for targeted drug delivery
The blood-brain barrier plays an important role in protecting the human brain from harmful toxins. But it also stops potentially helpful drugs from reaching the brain. Now, researchers believe that tiny bubbles loaded with drugs and delivered using ultrasound could overcome the obstacles presented by the protective network of vessels. Researchers at the University of […]