OncoSec Medical (NSDQ:ONCS) said today that it inked a preclinical deal with Jounce Therapeutics (NSDQ:JNCE) through the OncoSec Technology Access Program. According to the agreement, Jounce will have access to OncoSec’s gene delivery technology to assess the efficacy of intratumorally-delivered therapeutic candidates. The deal includes OncoSec’s Genesis research generator, which features customizable electroporation parameters for […]
Preclinical Trials
Nanoparticles use 2 mechanisms to boost immunotherapy
Cancer immunotherapy, a treatment approach that has gained momentum over the past few years, only helps a small fraction of patients. But researchers from the Johns Hopkins University School of Medicine have developed a nanoparticle that may one day help expand the patient population that benefits from immunotherapy. Immunotherapy usually falls into 1 of 2 […]
Small Utah biotech regenerates skin, hair in pigs
Utah-based biotech PolarityTe Inc. (NSDQ:COOL) has successfully regenerated skin and triggered hair growth in pigs with burns and abrasions. The breakthrough is a win in regenerative medicine, especially for tissue engineers hoping to help burn victims recover their skin. The firm’s approach involves using a patient’s own healthy tissue to grow human skin as a […]
Biopolymer tested as long-acting glucose control therapy
Researchers from Duke University have developed a biopolymer that could provide weeks of glucose control for patients with diabetes – in a single injection. The controlled-release treatment lasted for weeks in primates, according to a study published in Nature Biomedical Engineering. The biomedical engineers suggested that this new, injectable solution could replace daily or weekly insulin shots for […]
Hydrogel tech boosts success of transplanted insulin-producing cells
A hydrogel material embedded with a protein to improve blood vessel growth may boost the success rate of transplanting insulin-producing islet cells into patients with Type I diabetes, according to a preclinical study published in the journal Science Advances. In the newly-published work, supported by the National Institutes of Health and the Juvenile Diabetes Research Foundation, […]
Nanoparticles: An industry buzzword meets reality
Young startups backed by nanoparticle tech face a world hurdles before reaching the clinic. It’s been decades since the first innovations with nanotechnology – and experts are asking, “Where are all the drugs?” It’s been more than 20 years since the FDA approved the first nanoparticle drug, Doxil. At the time, nanoparticles were heralded as a […]
Nano-drug hitchhikes on white blood cells directly to tumor site
Researchers from Washington State University have developed a way to target drug delivery to a tumor by attaching the therapeutic to white blood cells. The discovery, which the team describes as a 1st of its kind, could help doctors provide more targeted cancer treatment. The researchers attached a nanoscale particle to a white blood cell […]
Researchers combine modified insulin and red blood cells to regulate blood sugar in diabetic mice
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have designed a glucose-responsive “smart” insulin delivery system using modified insulin and red blood cells. In an animal study of mice with Type I diabetes, the system effectively reduced blood sugar levels for 48 hours. The team’s work was published […]
Nanoscale ‘slingshot’ shoots drug to infection site
Researchers from the University of Rome Tor Vergata and the University of Montreal have reported the design and synthesis of a nanoscale molecular slingshot made of DNA that could potentially shoot and target drugs to specific regions of the human body. The slingshot is made of a synthetic DNA strand that can be loaded with […]
Study: Nanoparticle shrinks tumor size by 80% in mouse model
Researchers from the Mayo Clinic have developed a type of cancer-fighting nanoparticle that is designed to shrink breast cancer tumors and prevent recurrence. In a mouse model, the therapy yielded a 70-80% reduction in tumor size and mice treated with the nanoparticles demonstrated resistance to future tumor recurrence a month later. The nanoparticle is coated […]
