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San Diego company aiming to target glioblastoma with nanotechnology-based approach

June 28, 2021 By Brian Buntz

Glioblastoma
Intermediate magnification micrograph of a glioblastoma. HPS stain image courtesy of Wikimedia.

Glioblastoma, which kills roughly Americans each year, remains challenging to treat. The emerging biopharmaceutical company Global Cancer Technology (GCT; San Diego) is developing a novel x-ray activated modality for drug delivery to treat glioblastoma.

GCT has a licensing agreement with the University of California, San Diego (UCSD) for a drug delivery platform that unites a nanocrystal to a prodrug that can be activated using radiosurgery. GCT has also acquired two patents for investigational drugs that can cross the blood-brain barrier. One is an inhibitor of phosphatidylinositol 3-kinase (PI3K), a type of enzyme involved in a number of cellular functions that facilitates rapid growth in glioblastoma. The other compound targets Vps34, a phosphatidylinositol 3-kinase. Both compounds modulate autophagy, a regenerative cellular process. According to UCSD researchers, autophagy yields amino acids that support tumor survival. Blocking autophagy could thus support immunotherapy.

Get the full story from our sister site, Drug Discovery & Development.

Filed Under: Drug-Device Combinations, Immunotherapy, Nanoparticles, Oncology Tagged With: GCT, Glioblastoma, Global Cancer Technology

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About Brian Buntz

The pharma and biotech editor of WTWH Media, Brian is a veteran journalist with more than 15 years of experience covering an array of life science topics, including clinical trials, drug discovery and development and medical devices. Before coming to WTWH, he served as content director focused on connected devices at Informa. In addition, Brian covered the medical device sector for 10 years at UBM. At Qmed, he overhauled the brand’s news coverage and helped to grow the site’s traffic volume dramatically. He had previously held managing editor roles on two of the company’s medical device technology publications. Connect with him on LinkedIn or email at bbuntz@wtwhmedia.com.

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