Merck & Co. (NSDQ:MRNA) scientists have explored fighting cancer by way of the STING (stimulator of interferon genes)-controlled innate immune pathway.
Now, the company has published research in Advanced Therapeutics detailing a preclinical study with its partner Vesselon Inc. that reported impressive pharmacokinetics results related to MSA-1, a STING agonist.
The researchers found that low intravenous doses of MSA-1 alone did not have anti-tumor properties. But pairing MSA-1 with Vesselon’s FDA-approved acoustically-active drug Imagent led to complete tumor regressions. Vesselon makes use of a phenomenon known as sonoporation, which involves a temporary opening of cell membranes as a result of ultrasound exposure.
Get the full story from our sister site, Drug Discovery & Development.