NanOlogy touts preclinical data for inhaled NanoPac cancer drug

NanOlogy touted results today from preclinical studies of its inhaled submicron particle formulation of paclitaxel, NanoPac.

The company said animal studies have shown prolonged retention of the cancer drug in lung tissue and significant tumor regression without adverse drug-related side effects.

NanOlogy plans to present the data from its preclinical studies at this year’s annual meeting of the American Society of Clinical Oncology in Chicago.

In a preclinical pharmacokinetic study, researchers examined how well NanoPac was retained following a single inhalation via a nose-only exposure chamber and found measurable amounts of the drug in the rat’s lung tissue at the end of the 14-day study.

Histologic analysis of a model treated with the inhaled NanoPac found that the drug resulted in a significant decrease in primitive tumor cell population and significant tumor regression, the company reported.

“In our initial PK study, inhaled NanoPac resulted in longer lung retention of drug at a higher concentration compared to systemically administered paclitaxel. The evidence seen in our preclinical PK and efficacy studies has given us the confidence to move forward with IND-enabling studies in preparation for clinical trials,” Dr. Gere diZerega, VP of medical affairs, said in prepared remarks.

Want to stay on top of DDBN content? Sign up for our e-mail newsletter for a weekly dose of drug-device news.

Theranos whistleblower Tyler Shultz to participate in keynote interview at DeviceTalks Boston At DeviceTalks Boston, Tyler Shultz will give attendees an inside look at Theranos and how he was able to sound the alarm after he realized the company was falling apart. Shultz will take attendees behind the story that everyone is talking about: the rise and fall of Elizabeth Holmes and her diagnostic company, Theranos. Join Shultz and 1,000+ medical device professionals at the 8th annual DeviceTalks Boston. REGISTER NOW