• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer
  • Advertise
  • Subscribe

Drug Delivery Business

  • Clinical Trials
  • Research & Development
  • Drug-Device Combinations
  • FDA
  • Pharmaceuticals
  • Policy

Novocure brings Optune tech to drug trial for glioblastoma

July 24, 2017 By Sarah Faulkner

NovocureNovocure (NSDQ:NVCR) said today that it joined a Phase Ib study to evaluate the safety of Celgene‘s (NSDQ:CELG) marizomib and temozolomide in combination with Optune for patients with newly-diagnosed glioblastoma.

The trial is the first to assess Optune, the company’s “Tumor Treating Fields” delivery device, in combination with an investigational drug.

Celgene and Triphase changed their ongoing Phase Ib study of marizomib in combination with temozolomide and radiotherapy to include Optune. A group of 12 gliobastoma patients will be treated with the combination therapy following initial treatment with radiation and temozolomide, according to St. Helier, N.J.-based Novocure.

The primary endpoint for the study’s Optune branch is to evaluate the safety of the combination treatment with the addition of Optune. Secondary endpoints include preliminary clinical activity of the combo, Novocure said, including progression-free survival and overall survival.

The Optune arm is slated to open in the third quarter of this year.

The FDA-approved Optune device delivers low-intensity, intermediate frequency, alternating electric fields to inhibit cancer cell replication.

“This collaboration marks an important first step toward testing Optune with a promising new investigational compound for the treatment of GBM,” principal investigator Dr. Roger Stupp, associate director for strategic initiatives at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, said in prepared remarks. “Optune is the first treatment in over a decade to improve survival in GBM. I believe that combining Optune with new pharmacologic treatments in clinical trials, like this Phase Ib study, will help advance our understanding of how to treat this devastating disease.”

“We believe TTFields has the potential to be an excellent development candidate in combination with other solid tumor cancer treatments,” chief science officer & head of R&D, Eilon Kirson, added. “As innovators in cancer treatment, we know collaboration is essential to improve patient outcomes. We hope this is the first collaboration of many.”

Want to stay on top of DDBN content? Sign up for our e-mail newsletter for a weekly dose of drug-device news.

Filed Under: Clinical Trials, Drug-Device Combinations, Featured, Neurological, Oncology, Pharmaceuticals, Wall Street Beat Tagged With: Celgene, NovoCure

IN CASE YOU MISSED IT

  • Breaking: Sequel to launch twiist automated insulin delivery system next month
  • Dexcom shares U.S. report on CGM benefits for type 2 diabetes
  • Study backs Tandem automated insulin delivery in pregnant women with type 1 diabetes
  • Data backs Medtronic MiniMed 780G for type 2, children as company seeks expanded indications
  • Abbott could pave new roads in diabetes management with dual sensor on the horizon

Primary Sidebar

“ddb
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in drug delivery.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.

Footer

Drug Delivery Business News Logo

MassDevice Medical NETWORK

MassDevice
DeviceTalks
Medical Tubing + Extrusion
Medical Design & Outsourcing
MedTech100 Index
Drug Discovery & Development
Pharmaceutical Processing World
Medical Design Sourcing
R&D World

DRUG DELIVERY BUSINESS NEWS

Subscribe to Drug Delivery’s E-Newsletter
Advertise with us
About
Contact us
Privacy
Listen to our Weekly Podcasts

Copyright © 2025 · WTWH Media LLC and its licensors. All rights reserved.
The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media.

Privacy Policy | RSS