Keystone Nano said today that it has begun clinical testing for its ceramide NanoLiposome cancer therapy. The Phase I trial plans to evaluate the company’s NanoLiposome as a targeted treatment for solid tumors. Ceramide is a lipid that has demonstrated efficacy in liver cancer, breast cancer, leukemia and pancreatic cancer. Preclinical evidence has shown that […]
Oncology
Liposomal drug delivery system could improve solid tumor treatment
The oxygen-poor regions of solid tumors usually help make them resistant to chemotherapy and other forms of treatment. But researchers at Oregon State University have devised away to take advantage of those hypoxic areas and improve solid tumor treatment with a targeted, liposomal drug delivery system. The team used the cancer drug, vinblastine, which is […]
Study: Nanoparticles could improve efficacy of cancer immunotherapy
Researchers from the University of North Carolina have discovered that they can potentially improve cancer immunotherapy drugs by binding 2 compounds to a single nanoparticle. The team’s work was presented this week at the annual meeting of the American Association for Cancer Research. “Our data shows that 2 compounds on a single nanoparticle will make […]
Novocure touts long-term data for Optune, chemo combination therapy for glioblastoma
Shares in Novocure (NSDQ:NVCR) jumped nearly 50% today after the company touted 5-year data today from the Phase III pivotal EF-14 trial evaluating its Optune device with temozolomide chemotherapy as a treatment for newly-diagnosed glioblastoma. Data from 695 patients showed a consistent and maintained improvement in overall survival at 2, 3, 4 and 5 years, […]
RenovoRx wins label expansion for RenovoCath device
RenovoRx said yesterday that it won label expansion for the RenovoCath dual-balloon infusion catheter to include the delivery of chemotherapeutics. The device isolates segments of the peripheral vasculature, allowing doctors to deliver therapeutics in a more targeted fashion, according to the Los Altos, Calif.-based company. “This additional FDA indication marks yet another milestone for RenovoRx as […]
Researchers develop polymer capsules for targeted drug delivery
Researchers at the University of Alabama at Birmingham have developed cancer-fighting polymer capsules that they suggest could be used for targeted drug delivery of chemotherapeutics. The team’s work was published in ACS Nano. The multi-layer capsules feature good imaging contrast, as well as efficient encapsulation of doxorubicin, according to the researchers. The vessels are triggered by […]
Study: Why even targeted lung cancer therapies eventually fail
Even when patients are treated with targeted cancer therapies, many lung cancer patients suffer a recurrence. Researchers at Cold Spring Harbor Laboratory wanted to uncover how some cancers escape the power of targeted treatment. Their work was published in the journal eLife this week. The team of scientists, lead by Raffaella Sordella, found that a tiny subset […]
Aura Biosciences wins fast track designation for light-activated nanoparticle therapy
Aura Biosciences said today that it enrolled and dosed the 1st patient in the Phase Ib trial of its light-activated AU-011 viral nanoparticle conjugate therapy for the treatment of ocular melanoma. The company also said that the FDA granted fast track designation to its targeted treatment, which will give priority review for the company’s New Drug […]
Researchers develop ‘nano cage’ to study cancer cell growth
Researchers at Kent State University and Kyoto University published work this week describing the genetic factors that help turn healthy cells into cancerous cells. The team’s work was published in Nature Nanotechnology. “Traditionally, DNA has a 2-strand shape — the double helix — and its purpose is to code the proteins that form life,” co-author Hanbin […]
Study: Laser-activated gold microstructures deliver cargo directly into cells
Researchers from the Harvard University’s John A. Paulson School of Engineering and Applied Sciences have developed a method to deliver molecules into cells using gold microstructures. The team published their work in ACS Nano. Previous work has been done to deliver drugs or DNA into cells by tricking or forcing open the cell membrane, but the […]
