A team of researchers from MIT developed an ingestible, blueberry-sized capsule that can deliver insulin orally. In animal models, the capsule lowered blood sugar levels and performed comparably with the traditional route of insulin delivery – injections. The capsule features a small needle made of freeze-dried, compressed insulin. The needle is attached to a compressed […]
Researchers design ingestible sensor for controlled drug release
Researchers from MIT, Brigham & Women’s Hospital and Draper have developed a Bluetooth-controlled ingestible capsule that can sense the temperature of its environment and reside in the stomach for at least a month. The device, which was tested in an animal study and composed of 3D-printed parts, is powered by a small silver oxide battery […]
Researchers use microparticles for targeted delivery of brain cancer therapy
A team of researchers from Brigham & Women’s Hospital, Mass. Institute of Technology and Mass. General Hospital demonstrated that localizing the delivery of NAMPT inhibitors can extend survival in a mouse model of glioma, according to a paper published this week in the Proceedings of the National Academy of Sciences. The scientists created a test to […]
Acorda’s CEO on failure, perseverance and the profound risks of drug development
Dr. Ron Cohen isn’t easily deterred. The physician-turned-executive has spent decades in the biotech industry and weathered a number of setbacks – he learned in his early years at the now-defunct Advanced Tissue Sciences that to succeed, he needed resilience. “I learned that it took hundreds of millions of dollars if not billions to develop […]
Researchers deliver cardiac stem cell therapy in preclinical trial using refillable patch
Researchers have developed a small device designed to halt the effects of a heart attack by delivering a stem cell therapy directly to damaged cardiac tissue. In a study published in Nature Biomedical Engineering, researchers from Harvard University, the Massachusetts Institute of Technology, the National University of Ireland Galway and Trinity College Dublin reported that the […]
MIT researchers send drug-ferrying nanoparticles across the blood-brain barrier
Researchers at the Massachusetts Institute of Technology demonstrated in an animal study that nanoparticles shuttling two different cancer drugs could effectively cross the blood-brain barrier and target tumor cells. The team of scientists evaluated the drug combination in mice that had gliobastoma – an aggressive form of brain cancer that is notoriously hard to treat. […]
MIT researchers devise single-injection delivery method for polio vaccine
Although most of the world is protected from the polio virus thanks to a vaccine developed decades ago, some countries remain vulnerable to the disease thanks to challenges posed by a vaccine that requires repeat dosing. Researchers from the Massachusetts Institute of Technology want to change that with a nanoparticle vaccine that can deliver multiple […]
MIT study reveals the problem with bioresorbable stents
Bioresorbable coronary scaffolds, designed to avoid the risks associated with the long-term implantation of metal stents, once captured the attention of medtech giants like Abbott (NYSE:ABT) and Boston Scientific (NYSE:BSX). But companies have since linked the use of these biodegradable polymer-based devices to a heightened risk of myocardial infarction and thrombosis, prompting Abbott to pull its Absorb […]
Researchers develop capsule to deliver a week’s worth of HIV drugs
A team of researchers from the Massachusetts Institute of Technology and Brigham & Women’s Hospital have developed a drug-delivery capsule that can deliver a week’s worth of HIV drugs in a single dose. The technology is designed to make it easier for people with HIV to deal with the strict schedule of medications they need […]
How slugs, snails & worms inspired Gecko Biomedical’s biocompatible sealant
The story behind Gecko Biomedical’s biocompatible sealant starts in the summer of 2009, when Boston Children’s Hospital‘s chief of cardiac surgery reached out to Jeffrey Karp about a problem he was experiencing in the operating room. Dr. Pedro del Nido told Karp, a professor of medicine at Harvard and the director of the Laboratory for […]
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