Harvard Apparatus is boasting of the abilities of its Pump 11 Elite Nanomite – a single syringe infusion/withdrawal programmable syringe pump designed for precise point infusion applications. Researchers used the Pump 11 Elite Nanomite to successfully perform injections into specific sub-regions of the caudate nucleus in the brain. They repeatedly injected a 1 mm diameter target in […]
Neurological
Nobilis, Submersible Systems to develop hand-held inhalation device for neurological drugs
Nobilis Therapeutics said today that it partnered with device manufacturer Submersible Systems to develop a portable, hand-held inhalation device that administers a xenon gas-based therapeutic, NBTX-001. The companies said they are working on customizing and testing the drug-device combination. The group plans to pursue regulatory approval with the FDA, supported by upcoming clinical trials in […]
Patients with Parkinson’s disease help shape clinical trial design
Margaret Sheehan isn’t a scientist, but she is 1 of many patient scientists joining an effort to incorporate Parkinson’s patients’ preference into the design of clinical trials for new treatments. Sheehan, a Virginia-based lawyer, has had Parkinson’s disease since 2004. She told Drug Delivery Business News that when the folks at the Medical Device Innovation Consortium presented last spring […]
Antidepressant could help get drugs across blood-brain barrier
Researchers at the National Institutes of Health have found that pairing an antidepressant with neurological drugs can enhance drug delivery to the brain. The team’s research was published online in the Journal of Cerebral Blood Flow and Metabolism. The team cautioned that more work needs to be done to determine if the discovery will hold up […]
Midazolam nasal spray trial meets primary endpoint in patients with seizure clusters
Proximagen Ltd. said today that its pivotal Phase III trial of intranasal midazolam met its primary efficacy endpoint as a treatment for patients with seizure clusters. The Cambridge-based company said it plans to begin talks with the FDA for a New Drug Application in the 2nd half of this year based on the trial’s findings. […]
Acorda misses on Q1 earnings, slashes expense guidance after restructuring
Shares in Acorda Therapeutics (NSDQ:ACOR) fell today after the biopharmaceutical company missed expectations on Wall Street with its 1st quarter results. The Ardsley, N.Y.-based company posted a net loss of -$18.9 million, or -41¢ per share, on sales of $119.4 million for the 3 months ended March 31. In the same quarter last year, Acorda reported […]
Braeburn’s risperidone implant meets primary endpoint in schizophrenia trial
Braeburn Pharmaceuticals said yesterday that a 6-month study of its risperidone implant in patients with schizophrenia or schizoaffective disorder met its primary endpoint. Risperidone, the most commonly-prescribed therapy for schizophrenia, depends on consistent administration, but patients with schizophrenia sometimes stop taking their medication when their symptoms improve. Long-acting, injectable formulations of risperidone are on the market, […]
Medtronic updates 2011 battery warning on Synchromed II implantable drug pumps
Medtronic (NYSE:MDT) this month updated physicians on a warning it 1st issued in July 2011 about the batteries in its SynchroMed II implantable drug infusion pump. The pumps are used primarily to treat chronic pain or severe spinal or cerebral spasticity. The issue, 1st reported in July 2009, relates to the formation of a filmy substance within the […]
Nanoparticle nasal spray targets drugs to the brain
Drug delivery to the brain could 1 day be as simple as a sniff, according to engineers at Washington University that developed a new nanoparticle-based delivery technique. “This would be a nanoparticle nasal spray, and the delivery system could allow a therapeutic dose of medicine to reach the brain within 30 minutes to one hour,” […]
Homing system targets drugs to specific neurons
Researchers from Duke University and the Howard Hughes Medical Institute have developed a technique to target and deliver drugs to specific types of neurons in the brain. The team argues that this will enable scientists to more accurately study neurological disease while offering a more targeted treatment method. The current method of treatment for neurological […]