Parvus Therapeutics said today that it signed an exclusive worldwide license and collaboration deal with Novartis (NYSE:NVS) for its type 1 diabetes nanodrug, Navacim. The therapeutic candidate is made up of iron oxide nanoparticles coated with a peptide derived from a pancreatic autoantigen, according to Parvus. Navacims are the 1st biopharmaceuticals to restore immune tolerance through […]
Nanoparticles
Study: Biodegradable nanoparticles reprogram immune cells to fight cancer
Researchers at the Fred Hutchinson Cancer Researcher Center have reportedly engineered biodegradable nanoparticles that can genetically reprogram immune cells to recognize and destroy cancer cells, without taking the immune cells out to manipulate them. The team demonstrated their idea in a proof-of-principle study published in Nature Nanotechnology. They showed that reprogrammed immune cells, or T cells, help […]
Nanoparticles permeate lungs to deliver pulmonary drugs
Researchers from Johns Hopkins University have developed nanoparticles that can shuttle chemicals through the thick mucus membranes of pulmonary airways to deliver drugs. The team’s work was published in the journal Science Advances. Traditional therapies for cystic fibrosis, COPD and asthma include inhaled corticosteroids that adhere to the walls of air passages. Thick mucus tends to build […]
Keystone Nano launches clinical trial for NanoLiposome cancer therapy
Keystone Nano said today that it has begun clinical testing for its ceramide NanoLiposome cancer therapy. The Phase I trial plans to evaluate the company’s NanoLiposome as a targeted treatment for solid tumors. Ceramide is a lipid that has demonstrated efficacy in liver cancer, breast cancer, leukemia and pancreatic cancer. Preclinical evidence has shown that […]
Liposomal drug delivery system could improve solid tumor treatment
The oxygen-poor regions of solid tumors usually help make them resistant to chemotherapy and other forms of treatment. But researchers at Oregon State University have devised away to take advantage of those hypoxic areas and improve solid tumor treatment with a targeted, liposomal drug delivery system. The team used the cancer drug, vinblastine, which is […]
Researchers develop polymer capsules for targeted drug delivery
Researchers at the University of Alabama at Birmingham have developed cancer-fighting polymer capsules that they suggest could be used for targeted drug delivery of chemotherapeutics. The team’s work was published in ACS Nano. The multi-layer capsules feature good imaging contrast, as well as efficient encapsulation of doxorubicin, according to the researchers. The vessels are triggered by […]
Aura Biosciences wins fast track designation for light-activated nanoparticle therapy
Aura Biosciences said today that it enrolled and dosed the 1st patient in the Phase Ib trial of its light-activated AU-011 viral nanoparticle conjugate therapy for the treatment of ocular melanoma. The company also said that the FDA granted fast track designation to its targeted treatment, which will give priority review for the company’s New Drug […]
Researchers tout preclinical results for one-shot vaccination method
Researchers from Boston Children’s Hospital said today that they achieved strong vaccine responses in preclinical models by adding adjuvants to boost the immune response. The team’s work was published the Journal of Clinical Investigation-Insight and the Journal of Allergy and Clinical Immunology. Vaccines have the potential to drastically reduce infant mortality, the researchers said, but newborns often don’t […]
Study: Tethered nanoparticles help trigger cell death in cancerous tumor cells
Researchers from the Massachusetts Institute of Technology have developed a way to amplify certain types of cancer treatment by tethering nanoparticles to cancerous tumor cells. The team’s work was published in Nature Communications. The researchers found that tethered nanoparticles increase the forces exerted on the cells by phenomena such as blood flow, therefore making the cells […]
Penn State researchers deliver melanoma drug combo using nanoparticles
Researchers from the Penn State College of Medicine developed a method to deliver a combination of drugs using nanoparticles in the hopes of preventing melanoma cancer cells from developing treatment-resistance. Their work was published in Molecular Cancer Therapeutics and Cancer Letters. The team’s CelePlum-777 localized around cancer tumors and delivered a specific ratio of an anti-inflammatory, Celecoxib, and a toxin, Plumbagin, […]
