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Preclinical Trials

Microneedle skin patch delivers fat-burning drug in mouse trial

September 15, 2017 By Sarah Faulkner

Researchers have created a drug-filled microneedle skin patch that helps convert energy-storing fat, or white fat, into energy-burning fat, or brown fat – all the while boosting the body’s metabolism. The team of researchers at Columbia University Medical Center and the University of North Carolina reported that their patch could one day be used to burn […]

Filed Under: Diabetes, Drug-Device Combinations, Featured, Pharmaceuticals, Preclinical Trials, Research & Development Tagged With: columbiauniversity, University of North Carolina

Icon beats Street on Q2 earnings, acquires Mapi Group

July 27, 2017 By Chris Newmarker

Icon PLC

Drug development provider Icon PLC (Nasdaq: ICLR) saw its stock jump about 6% in value today after announcing second-quarter earnings that beat analysts’ expectations. The Dublin, Ireland–based company, which serves the pharmaceutical, biotechnology and medical device industries, also said it has acquired the Mapi Group, which provides patient-centered health outcomes research and commercialisation. Financial terms of […]

Filed Under: Business/Financial News, Clinical Trials, Contract Services, Drug-Device Combinations, Featured, Mergers & Acquisitions, Pharmaceuticals, Preclinical Trials, Regulatory/Compliance, Research & Development, Wall Street Beat Tagged With: iconplc

Nanotech derived from amniotic stem cells could help treat brain cancer

July 26, 2017 By Sarah Faulkner

Creative Medical Tech

Creative Medical Technology Holdings (OTC:CELZ) touted its exosome technology today, reporting that it demonstrated an ability to regenerate healthy brain cells while selectively halting the growth of glioma brain cancer cells in a preclinical model. The company’s exosomes are vesicles harvested from amniotic stem cell technology, which it licensed from the University of California San […]

Filed Under: Featured, Neurological, Oncology, Preclinical Trials, Stem Cells, Wall Street Beat Tagged With: creativemedicaltechnologyholdings, University of California San Diego

Study: Microneedle patch, protein combo could boost efficacy of flu vaccine

July 20, 2017 By Sarah Faulkner

Researchers at Georgia State University and Georgia Institute of Technology have devised a method to boost the efficacy of a traditional influenza vaccine. The team combined a fusion protein into a microneedle patch made from a biocompatible polymer. The patch’s needles are biodegradable, releasing vaccine into the skin as they dissolve. Mice receiving a conventional […]

Filed Under: Drug-Device Combinations, Featured, Pharmaceuticals, Preclinical Trials, Research & Development Tagged With: Georgia Institute of Technology, georgiastateuniversity

Synspira’s therapy could boost antibiotics against drug-resistant bacteria in CF patients

July 12, 2017 By Sarah Faulkner

Synspira

Privately-held Synspira touted a study today of its inhaled glycopolymer-based therapeutic with antibiotics as a potential treatment for pulmonary infection caused by the Burkholderia cepacia complex in patients with cystic fibrosis. The study was published in PLOS One. Synspira’s lead polycationic glycopolymer, SNSP113, was studied in combination with tobramycin and meropenem. These antibiotics, as well as ceftazidime, are often […]

Filed Under: Drug-Device Combinations, Featured, Pharmaceuticals, Preclinical Trials, Research & Development, Respiratory Tagged With: synspira

Capillary Biomedical takes aim at ‘the Achilles heel of diabetes’

July 7, 2017 By Sarah Faulkner

Capillary Biomedical

Major players in the medical device realm are in a heated race to develop the first artificial pancreas to help patients with diabetes manage the chronic condition. Just last year,  Medtronic (NYSE:MDT) won FDA approval for its MiniMed 670G hybrid-closed loop system. But while companies compete for the top spot in developing what could be a […]

Filed Under: Diabetes, Drug-Device Combinations, Featured, Pharmaceuticals, Preclinical Trials, Research & Development Tagged With: capillarybiomedical

GSK inks deal for AI-driven drug discovery

July 3, 2017 By Sarah Faulkner

Exscientia inked a drug discovery collaboration with GlaxoSmithKline (NYSE:GSK) that could bring the Scotland-based company up to $37.5 million. As a part of the deal, Exscientia plans to use its artificial-intelligence platform to discover small molecules for up to 10 disease-related targets, as chosen by GSK. GSK is slated to pay Exscientia in preclinical candidate milestone […]

Filed Under: Big Data, Featured, Pharmaceuticals, Preclinical Trials, Wall Street Beat Tagged With: exscientia, GlaxoSmithKline plc

Plant-virus nanoparticles combined with chemo delays tumor progression

June 28, 2017 By Sarah Faulkner

Case Western Reserve University

Researchers from Case Western Reserve University School of Medicine, Dartmouth Geisel School of Medicine and RWTH Aachen University have demonstrated that injecting nanoscale potato-virus particles and doxorubicin into melanoma tumors slows tumor progression in mice. The team’s work was published in Nano Letters. Although simultaneous injection of the virus particles and a chemo drug prompted a […]

Filed Under: Featured, Nanoparticles, Oncology, Preclinical Trials, Research & Development

OncoSec inks preclinical deal with Jounce Therapeutics

June 13, 2017 By Sarah Faulkner

OncoSec Medical

OncoSec Medical (NSDQ:ONCS) said today that it inked a preclinical deal with Jounce Therapeutics (NSDQ:JNCE) through the OncoSec Technology Access Program. According to the agreement, Jounce will have access to OncoSec’s gene delivery technology to assess the efficacy of intratumorally-delivered therapeutic candidates. The deal includes OncoSec’s Genesis research generator, which features customizable electroporation parameters for […]

Filed Under: Drug-Device Combinations, Featured, Preclinical Trials Tagged With: jouncetherapeutics, OncoSec Medical

Nanoparticles use 2 mechanisms to boost immunotherapy

June 12, 2017 By Sarah Faulkner

Nanoparticle immunotherapy

Cancer immunotherapy, a treatment approach that has gained momentum over the past few years, only helps a small fraction of patients. But researchers from the Johns Hopkins University School of Medicine have developed a nanoparticle that may one day help expand the patient population that benefits from immunotherapy. Immunotherapy usually falls into 1 of 2 […]

Filed Under: Featured, Immunotherapy, Nanoparticles, Oncology, Preclinical Trials, Research & Development Tagged With: Johns Hopkins

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